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CP-466722，ATM/ATR 抑制剂，ATM/ATR inhibitors别名:CP466722分子量 (MW):349.35化学式:C17H15N7O2溶解度: DMSO 0.28mg/mL Water <1mg/mL Ethanol <1mg/mL稳定性:at -20℃ 2 yearsCAS号:1080622-86-1
更新时间：2016-04-03
| 分子量（MW）: | 349.35 |  |
|---|---|---|
| 化学式: | C17H15N7O2 | |
| 溶解度: | DMSO 0.28mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 1080622-86-1 |
CP-466722 is rapidly reversible potential ATM kinase inhibitor. CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and compley reversed by removing CP466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies. [1]
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