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CHIR-99021
上海义森生物科技有限公司提供：Tideglusib，GSK-3 抑制剂，GSK-3 inhibitors生物活性
技术数据:
分子量（MW）: 501.8 化学式: C22H18Cl2N8.HCl
溶解度: DMSO 100mg/mL Water 100mg/mL Ethanol 20mg/mL 纯度: >99% 稳定性: at -20℃ CAS号: 252917-06-9 （free base）
生物活性
CHIR-99021 （CT99021） HCl is a glycogen synthase kinase 3β （GSK3β） inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases （CDKs） with 350-fold selectivity toward GSK-3β compared to CDKs . [1]
上海义森生物科技有限公司提供：Tideglusib，GSK-3 抑制剂，GSK-3 inhibitors
生物活性
技术数据:
分子量（MW）: 501.8 化学式: C22H18Cl2N8.HCl
溶解度: DMSO 100mg/mL Water 100mg/mL Ethanol 20mg/mL 纯度: >99% 稳定性: at -20℃ CAS号: 252917-06-9 （free base）
生物活性
CHIR-99021 （CT99021） HCl is a glycogen synthase kinase 3β （GSK3β） inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases （CDKs） with 350-fold selectivity toward GSK-3β compared to CDKs . [1]
上海义森生物科技有限公司提供：Tideglusib，GSK-3 抑制剂，GSK-3 inhibitors
技术数据:
| 分子量（MW）: | 501.8 | |
|---|---|---|
| 化学式: | C22H18Cl2N8.HCl | |
| 溶解度: | DMSO 100mg/mL Water 100mg/mL Ethanol 20mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ | |
| CAS号: | 252917-06-9 （free base） |
生物活性
CHIR-99021 （CT99021） HCl is a glycogen synthase kinase 3β （GSK3β） inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases （CDKs） with 350-fold selectivity toward GSK-3β compared to CDKs . [1]
