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CHIR-99021分子量 (MW):501.8化学式:C22H18Cl2N8.HCl溶解度: DMSO 100mg/mL Water 100mg/mL Ethanol 20mg/mL稳定性:at -20℃CAS号:252917-06-9 (free base)
更新时间:2024-09-10
分子量(MW): | 501.8 | |
---|---|---|
化学式: | C22H18Cl2N8.HCl | |
溶解度: | DMSO 100mg/mL Water 100mg/mL Ethanol 20mg/mL | |
纯度: | >99% | |
稳定性: | at -20℃ | |
CAS号: | 252917-06-9 (free base) |
CHIR-99021 (CT99021) HCl is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3β compared to CDKs . [1]