返回首页 | 加入收藏 | 联系我们

Products

产品目录

产品中心

您现在的位置:首页 > 产品中心 > SB 415286,GSK-3 抑制剂,GSK-3 inhibitors

SB 415286,GSK-3 抑制剂,GSK-3 inhibitors

分享到:

上海义森生物科技有限公司提供:SB 415286,GSK-3 抑制剂,GSK-3 inhibitors

 

生物活性

技术数据:

分子量(MW): 359.72 SB 415286 Chemical Structure
化学式:

C16H10ClN3O5

溶解度: DMSO 72mg/mL   Water <1mg/mL   Ethanol 72mg/mL
纯度: >99%
稳定性: at -20℃ 2 years
CAS号: 264218-23-7

生物活性

 

SB 415286 is a potent and selective cell-permeable, ATP-competitive GSK3α inhibitor with an IC50 and a Ki of 78 and 31 nM, respectively. SB 415286 competes with ATP. SB 415286 has minimal activity against 24 other protein kinases (IC50 > 10 μ M). SB 415286 stimulates glycogen synthesis, gene transcription and is neuroprotective. As a result of GSK3 inhibition, SB 415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 µM. SB 415286 also protects primary neurons from death induced by the PI3-kinase pathway. In L6 myotubes, SB 415286 induced a much greater activation of GS (6.8-fold) . In adipocytes, SB 415286 caused a comparable activation of GS despite a substantial differentiation-linked reduction in GSK3 expression ( approximay 85%) indicating that GSK3 remains an important determinant of GS activation in fat cells. [1] SB 415286 induced expression of a beta-catenin-LEF/TCF regulated reporter gene in HEK293 cells. [2]

 

参考文献

  • Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. MacAulay K et al. Eur J Biochem 2003 Sep;270(18):3829-38
  • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Coghlan MP et al. Chem Biol 2000 Oct;7(10):793-803
上海义森生物科技有限公司提供:SB 415286,GSK-3 抑制剂,GSK-3 inhibitors

 

 

 如果你对SB 415286,GSK-3 抑制剂,GSK-3 inhibitors感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7

供应Wistar孕鼠,BALB/c-nu裸鼠,SD大鼠,F1代小鼠,DBA/2小鼠,CBA/ca小鼠,BN大鼠,C3H/He,F344大鼠,129/Se小鼠,LEWIS大鼠,Wistar大鼠,ICR小鼠,KM小鼠,C57小鼠,BALB/c小鼠等。
关于我们 | 产品展示 | 新闻中心 | 在线留言 | 联系我们 |

联系电话:18018648472  |  传真:021-54320576

凯学生物科技(上海)有限公司(www.yisonbio.com)版权所有
沪ICP备2021028108号-1
点击这里给我发消息
电话:
18018648472
手机:
18018648472